P118 CXCL13 AS A NOVEL POTENTIAL BIOMARKER OF ESSENTIAL HYPERTENSION
Yanina Timasheva, В. В. Эрдман, Т. Р. Насибуллин, Ilsiyar A. Tuktarova, Olga Evgen'evna Mustafina · Artery Research · 2018
Results: Black men and women had higher blood pressure (p < 0.001), higher IL-6 (p 0.016), shorter telomeres (p < 0.001) but similar NOx levels when compared to their white counterparts.GPx activity was higher and L-citrulline lower in black compared to white groups (p 0.002).Independent positive associations of telomere length with NOx (adj R 2 Z0.21;bZ0.249;pZ0.03)and GPx activity (adj R 2 Z0.21;bZ0.229;pZ0.03)were indicated in white men and TNF-a (adj R 2 Z0.33;ÀbZ0.274;pZ0.01) in white women.These associations were absent in the black groups.Conclusion: Telomere length of black men and women was shorter but not associated with NOx and age or markers of oxidative stress and inflammation, as observed in the white groups.Therefor it seems that the less favourable cardiovascular and inflammatory profiles of blacks were unrelated to shorter telomere lengths.The lower L-citrulline levels indicate decreased NO synthesis that may affect the association between telomere length and NOx.