ReDO_DB: the repurposing drugs in oncology database
Pan Pantziarka, Ciska Verbaanderd, Vidula V. Sukhatme, Rica Capistrano, Sergio Crispino, Bishal Gyawali, Ilse Rooman, An M. T. Van Nuffel, Lydie Meheus, Vikas P. Sukhatme, Gauthier Bouche · ecancermedicalscience · 2018
Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment of clinical trial activity also described. The database has been made available as an online open-access resource (http://www.redo-project.org/db/).