Screening of cytochrome P450 3A4 inhibitors via in silico and in vitro approaches
Xiaocong Pang, Baoyue Zhang, Guangyan Mu, Jie Xia, Qian Xiang, Xia Zhao, Ailin Liu, Guanhua Du, Yimin Cui · RSC Advances · 2018
values of 0.052 and 1.120 μM, respectively. This study proved the feasibility of a new method for predicting CYP3A4 inhibitory activity and preventing the occurrence of DDIs at early stage in drug development.