Lead Developer Angular and Effect of Force by Side Chain of Suicide Molecule in HIV AIDS Drug Discovery
Rahul Hajare · Journal of Pharmaceutical Research and Reviews · 2018
Angular to lead (A2L) accepted as lead generation has stage in early drug discovery where small molecule hits from a high throughput screen (HTS) has evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery. Angular imagination → Target validation (TV) → assay development → high-throughput screening → hit to lead (H2L) → lead optimization (LO) → preclinical drug development → clinical drug development.