Role of preclinical pharmacokinetics in New Chemical Entity (NCE) development: A review
Sakshi Negi, Ashutosh Badola · Asian Journal of Pharmacy and Pharmacology · 2018
The cost of bringing new chemical entity (NCE) is very expensive and long process and the chances of failure during clinical trials are very high.Inadequate pharmacokinetic data is the major problem and failure of new drug during clinical phase therefore in order to decrease drug failure rates preclinical studies such as and in vitro in vivo pharmacokinetic studies are being conducted.At present, most pharmaceutical companies perform and in vitro in vivo studies together with prediction softwares.The data obtained during preclinical phase helps in eliminating in silico weaker candidate and reduce attrition rate.The aim of this review is to focus on various methods employed during preclinical phase.