Open source Bioinformatics tools for the development of new TB drugs
Lucas A. Defelipe, Leandro Radusky, Carlos Pablo Modenutti, Ezequiel Jorge Sosa, Darío Fernández Do Porto, Marcelo Adrian Marti, Adrian Gustavo Turjanski · International Journal of Infectious Diseases · 2018
Background: In 2016 an estimated 6.3 million people developed tuberculosis (TB), and 1.8 million died from the disease. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the negative drug-drug interactions with HIV (or another disease) treatments and the ineffectiveness of current drugs against dormant Mtb.