How Do We “Validate” a QSP Model?
Daniel C. Kirouac · CPT Pharmacometrics & Systems Pharmacology · 2018
This is a question that arises recurrently, both in the process of publishing Quantitative Systems Pharmacology (QSP) research -and more critically for those making drug development decisions based on model simulations.Although previous commentaries have addressed this issue, 1 there is still no agreed-upon answer.Using the associated article by Zhu et al. 2 as an example, I will describe how Virtual Populations can be used to assess confidence in qualitative predictions from QSP models.