DELINEATION OF CALCIUM DIFFUSION IN ALZHEIMERIC BRAIN
Devanshi D. Dave, Brajesh Kumar Jha · Journal of Mechanics in Medicine and Biology · 2018
Under the widespread umbrella of dementia, Alzheimer’s disease is the most common form of dementia. Most of the aged people are suffering from Alzheimer’s disease around the world. The reasons for the same are not known in detail and thus various experimental and computational attempts need to be carried out. Calcium, being a second messenger has an immense role in transformation of information. This transformation takes place in the form of signaling in which several parameters play an active role. In present work, an attempt has been made to describe the effect of calcium signaling in nerve cells for Alzheimer’s disease. Here, parameters like advection diffusion and buffering are taken into consideration to visualize the effects of the same on cytosolic calcium concentration. This physiological process is modeled two dimensionally and solved analytically. Laplace and similarity transforms are employed to obtain the desired results. The results are simulated and graphically plotted using MATLAB. The known fact that the higher concentration of calcium has adverse effects on the cell which may result into progression of AD is considered as a lantern in enlightening the physiology of Alzheimer’s disease.