Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape
Marjoleen Nijsen, Fan Wu, Loveleena Bansal, Erica L. Bradshaw‐Pierce, Jason R. Chan, Bianca M. Liederer, Jerome Thomas Mettetal, Patricia E. Schroeder, Edgar L. Schuck, Alice Tsai, Christine R. Xu, Anjaneya Chimalakonda, Kha N. Le, Mark Penney, Brian Gregory Topp, Akihiro Yamada, Mary E. Spilker · CPT Pharmacometrics & Systems Pharmacology · 2018
A cross-industry survey was conducted to assess the landscape of preclinical quantitative systems pharmacology (QSP) modeling within pharmaceutical companies. This article presents the survey results, which provide insights on the current state of preclinical QSP modeling in addition to future opportunities. Our results call attention to the need for an aligned definition and consistent terminology around QSP, yet highlight the broad applicability and benefits preclinical QSP modeling is currently delivering.