Biological Potential of Synthetic Hydrazones in the Last Decade: A Systematic Review
Délis Galvão Guimarães, Larissa Araújo Rolim, Arlan de Assis Gonsalves, Cleônia Roberta Melo Araújo · Revista Virtual de Química · 2017
Hydrazones are a class of organic compounds with the general structure -C=N-NH-, resulting from the condensation of carbonylated substances with amines.The synthesis of this functional group generally occurs by the condensation of hydrazines or hydrazides with aldehydes and ketones.In recent years, the functional group hydrazone has been gaining prominence in medicinal chemistry, due mainly to its wide spectrum of applications and chemical and biological properties, as well as its structural versatility.Thus, this systematic review is aimed to investigate the biological potential of hydrazones obtained synthetically in the last decade.Among the papers included in this study, over 80% of them exhibit promising results for the evaluation activity, and less than 15% of these had unimpressive results.In addition, the relationship and importance of the coordination properties of the hydrazonic derivatives for the evaluated activities became apparent.Moreover, synthetic hydrazones are promising organic substances for the research and development of new chemical prototypes for the discovery of new drugs.