SCREENING OF ANTIMICROBIAL EFFECT OF SOME NON-ANTIBIOTICS (ANTI-HYPERTENSIVE) AGAINST SOME SELECTED MICROORGANISMS
Saptarshi Das, R. P. Basak · Indian Research Journal of Pharmacy and Science · 2017
Antibiotics are most important series of drugs which are use over a large numbers of microbial infections, but in todays practice use of antibiotics in a desperate way creates its resistance in human physiological system and continuously narrow it's theraputic range.Despite their use is becoming increasingly restricted.The reason behind such a rapid decline is largely attributed to the development of drug resistance among microorganisms.Such a phenomenon is coupled by the toxicity possessed by many antimicrobials.For this taking in mind present scenario The aim of this study was to screen the antimicrobial activity of non-antibiotic drugs like antihypertensives.Calcium channel blockers like verapamil and beta blockers like propranolol showed highest activity for S.aureus and B.subtilis respectively.While ACE inhibitors like enalapril and ARBs like losartan showed highest activities for V.cholerae and S.typhii respectively.