Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research
Pengyue Zhang, Heng‐Yi Wu, Chien‐Wei Chiang, Lei Wang, Samar Binkheder, Xueying Wang, Donglin Zeng, Sara K. Quinney, Lang Li · CPT Pharmacometrics & Systems Pharmacology · 2017
Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation and informatic tools on integrating drug interaction knowledge and generating drug interaction hypothesis. We provide a comprehensive overview of these translational biomedical informatics methodologies with related databases. We hope this review illustrates the complementary nature of these informatic approaches and facilitates the translational drug interaction research.