Toxicity Assessment of Structurally Relevant Natural Products from Mexican Plants with Antinociceptive Activity
Karina Martínez‐Mayorga, Andrés F. Marmolejo-Valencia, Fernando Cortés‐Guzmán, Juan Carlos García‐Ramos, Eric Iván Sánchez‐Flores, Joaquín Barroso‐Flores, José L. Medina‐Franco, Baldomero Esquivel-Rodríguez · Journal of the Mexican Chemical Society · 2017
UNIIQUIM database contains molecules from Mexican plants, one of the richest sources of bioactive molecules in the world. Here, we describe the chemical and toxicological profile of molecules with analgesic activity from UNIIQUIM. Most of the compounds are likely to interact with opioid receptors. The predicted acute toxicity is low and none is predicted mutagenic. Given the structural diversity, and biological and toxicity profiles, these molecules represent a new avenue in the search of molecules with antinociceptive activity.