P1615Performance of four bleeding risk scores for the prediction of in-hospital bleeding events in patients with acute pulmonary embolism
M. Kozlowska, Aleksandra Furdyna, Karolina Uchacz, Bartosz Karolak, Michał Ciurzyński, Maciej Kostrubiec, Marcin Koć, Szymon Pacho, Katarzyna Kurnicka, Anna Wyzgał, A. Lipinska, Piotr Palczewski, Piotr Pruszczyk · European Heart Journal · 2017
Background: Bleeding is a major complication of anticoagulation, however no score holds sufficient predictive value for in-hospital anticoagulation-related bleedings in initial acute pulmonary embolism (APE) treatment. Purpose: To compare bleeding risk scores developed for atrial fibrillation (HASBLED, HEMORR2HAGES) and for venous thromboembolism (RIETE, VTE-BLEED) in prediction of in-hospital bleeding events in anticoagulated APE pts. Methods: A single center retrospective study of 388 pts hospitalized for APE. 225 pts (101 M, median age 70 yrs, 25th-75th percentile 59–83, median length of hospitalization 7 days, 5–10) according to ESC guidelines were identified as non-low risk of early mortality (itm-low 85 pts, itm-high 131 pts, high 9 pts), 163 low risk pts were excluded. Bleeding events were defined according to the ISTH. An univariate analysis of all components of the scores for all bleeding events was performed. ROC and AUC were calculated for the scores in regard to all bleedings and major bleedings, followed by a pairwise comparison of ROCs.