Database resources and their functionalities: ConsensusPathDB and ToxDB
Gal Barel, Christopher Hardt, Atanas Kamburov, Ralf Herwig · 2017
We present two database resources, ConsensusPathDB and ToxDB, display their functionalities and demonstrate how they can be used to carry out a system-wide approach for the HeCaToS project. ConsensusPathDB consists of a comprehensive collection of molecular interaction data integrated from 32 different public repositories and a web interface featuring a set of computational methods and visualization tools to explore these data. ToxDB was developed for the analysis of the functional consequences of drug treatment at the pathway level, and thus consists of 2,282 pathway concepts as well as numerical response scores for 437 drugs and 7,467 different experimental conditions. For the HeCaToS project we have used both resources and established an integrative approach for the identification and prediction of human liver and heart drug induced toxicity.