OC-0362: HDR brachytherapy boost with a single fraction: is it useful to preserve the breast in young woman with early cancer?
J.L. Guinot, M. Santos, Pablo Soler, Estefany Marlen Barragán Jiménez, Fernando López‐Campos, Alejandro Mut, E. Arregui, Araceli Moreno, L. Arribas · Radiotherapy and Oncology · 2013
2 nd ESTRO Forum 2013 S141 (r=-0.235,p=0.039), meaning greater BV variability was associated with reduced LENT-SOMA bladder scores.Conclusions: We believe that we are the first to document an association between interfraction variation of bladder volume and long-term bladder toxicity outcomes in image-guided ICB for cervical cancer.This is consistent with previous data showing that BV variation can avoid overlap of high dose regions within the bladder.Such data could justify changing current practice in many centers that do not routinely use variable bladder filling protocols.Nonetheless, study is ongoing to determine the exact effect of BV changes on distribution of high dose areas to further validate this recommendation.