Pharmacokinetics and pharmacodynamics of Atorvastatin alone and in combination with Lercanidipine in hyperlipidemic rats
Prasanna Katnapally, Anbu Janaki, A. Rama Narsimha Reddy, Narsimha Reddy Yellu · 2015
Received on:11-08-2008; Accepted on:11-11-2008 The present study was carried out to investigating the pharmacokinetics and pharmacodynamics of atorvastatin (AT) alone and in combination with lercanidipine (LER) in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected (on 1st and 8th day) from AT alone and in combination with LER treated groups and were analyzed for various pharmacokinetic parameters and lipid profiles. Atorvastatin caused a marked reduction in the lipid profiles in hyperlipidemic rats. The combination of AT and LER in hyperlipidemic rats produced a significant change in lipid profiles (pharmacodynamics) and insignificant change in the pharmacokinetics of atorvastatin when compared with AT alone. The results of present study, suggests synergistic activity of lercanidipine with atorvastatin. Key words: Atorvastatin, lercanidipine, hyperlipidemia and lipid lowering activity