Cancer Glycolysis I: Entropy Production and Sensitivity Analysis in Stationary State
S. Montero, Martin Rr, Ângela R. Guerra, O Casanella, G. Cocho, Nieto Villar JM · Journal of Adenocarcinoma · 2016
Using sensitivity analysis and entropy production rate 10 main reactions, among 20 regulating the glycolysis process of AS-30D hepatoma and HeLa tumor cell line in stationary state, were identified. In fact, these 10 fundamental reactions are potential targets in cancer therapy. A high correlation between entropy production rate and intracellular pHi was detected in this work.