2P032 1G1520 Protease Inhibition Modeling by Proteochemometrics using Topological Autocorrelation Features(The 48th Annual Meeting of the Biophysical Society of Japan)
Michael H. Fernandez, Shandar Ahmad, Akinori Sarai · Seibutsu Butsuri · 2010
JapanGeneral IncorporatedAssociation the protein is coordmated by two hisudmes (His40 andHis81) one cysteme (Cys78) and one methtontne {Met86) with distorted tetrahedral geometry Recently spectresLopic dnd electreLhemical properties et a site directed mu tdgLnLsis mutant Met16Hls haie been studied In order to furthel exp!ore ot the newly mtroduced His residue of Met16Hb, Mct16HisfHig6Vhl double mutantwasconstructed Perturbation of the ratio of the LMCT bands (A-4Ge!A-.aM]) by the substl tution at Metl6 rLfiects the structural changes around the active site The Tatio A..46o/Any6on of Metl6His and