Solid state characterization of atorvastatin in drug products
Haykel Galai, Malek Lemsi, Mohamed Radhouan Louhaichi, Mohamed ChihebBenrayana, Rafik Kalfat · Journal of chemical and pharmaceutical research · 2015
Two Atorvastatin marketed products with different composition and showing significant discrepancy in dissolution kinetics were subjected to solid state characterization. PXRD, DSC and FTIR didn’t show any remarkable differences in the API of the tablet. However, the 19F ssNMR showed a mixture of atorvastatin forms for the product indicating a lower dissolution.