An Analytical Approach to Modulating Effects of Heat Shock Proteins towards Immune Responses of Cancer in the Context of Protein Vibration
Brajagopal Majumder · International journal of biophysics · 2017
A brief account on cancer – one of the devastating diseases of the world has been outlined here. Cancer being a genetic disease arises from accumulation of mutations in critical genes. There are no unilateral reasons for its development. However, some proteins have by this time been identified for the development of cancer in human body. On the other hand, some proteins namely Heat shock proteins (Hsp) are induced either in different cancer affected cells or induced due to external administration of therapeutic agents including Indian medicinal herbs like Bacopa Monnicri etc. These are now found to modulate immune system by stimulating both innate and adaptive responses. Hsp – based therapeutic in cancer trials are also now available. One Hsp – band Vaccine Vitespen by name, made of Hsp gp - 96 is now licensed for use. This paper focuses on the dynamism of the use Hsp – 70, Hsp gp - 96 in the context of protein vibration approach due to electrostatic potential of the cell in the range of (0.8 to 1.0 and 25) mv. The potential range has arbitrary been choosen for sake of the paper. The paper also focuses on the process of modulation of the immune system by Hsp – 70 and gp – 96 basing on the frequency generated by the respective Hsp.