Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
Jéssica de Oliveira, Luciane Viater Tureck, Willian dos Santos, Louise Farah Saliba, Caroline Schovanz Schenknecht, Débora Scaraboto, Ricardo Lehtonen Rodrigues de Souza, Lupe Furtado Alle · Genetics and Molecular Biology · 2017
Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A 0.05). The dominant and recessive models were tested, and different effects were found. The -116A allele showed a dominant effect in BChE activity reduction in both non-obese and obese women (p = 0.045 and p G and 1615GA SNPs influenced the TG levels only in obese women. The 1914G and the 1615A alleles were associated with decreased plasma levels of TG. Thus, our results suggest that the obesity condition, characterized by loss of energy homeostasis, is modulated by BCHE polymorphisms.