COMPUTERIZED MORPHOMETRIC ASSESSMENT OF THE HUMAN RED BLOOD CELLS TREATED WITH CISPLATIN
Cristina Bischin, Ştefan Ţălu, Radu Silaghi‐Dumitrescu, Ştefan Ţălu, Stefano Giovanzana, Carmen Alina Lupaşcu · 2012
Summary The objective of this study is to perform an evalua tion of representative size and shape parameters that characterise the human red blood ce lls either exposed to cisplatin or exposed to control solutions containing no cisplati n. A set of fourteen digital images corresponding for the human red blood cells were evaluated. Image processing and analysis of digital images were performed with ImageJ and MRI Cell Image Analyzer (MRI-CIA) softwares. We found for the human red blood cells e ither exposed to cisplatin or exposed to control solutions containing no cisplatin, a set of representative size and shape parameters for quantification. The central tendency and disper sion measure of the parameters were expressed by the mean value and standard deviation. The computerized geometric morphometric analysis of the human red blood cells is an efficient noninvasive prediction tool that provides important insights into cell sta tes.