CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
Svetlana Yu. Nikulina, V. A. Schulman, O. O. Kuznetsova, N V Aksjutina, P. A. Shesternja, А. А. Чернова, Vladimir N. Maksimov, I. V. Kulikov, С. Н. Устинов, Y. L. Kazarinova, А. Г. Ромащенко, Mikhail Ivanovich Voevoda · Rational Pharmacotherapy in Cardiology · 2008
Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors. Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors. Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance. Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.