Systematic analysis of structural and activity relationships between conventional hierarchical and analog series-based scaffolds
Dagmar Stumpfe, Dilyana Dimova, Jürgen Bajorath · RSC Advances · 2017
Three pairs of compounds (left) belonging to three different analog series that differ in their biological activity share a single conventional hierarchical scaffold (BM, middle) but have distinct ‘analog series-based’ (ASB) scaffold (right).