Retrometabolic Approach for Designing Personalized Anti- Cancer Drug Molecules for Controlling Breast Cancer Resulted by BRCA1 Mutations
Preethi M. Iyer, Sanjay Palayat, Karthikeyan Shanmugam, P. K. Krishnan Namboori · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · 2017
Background: The drug response varies from person to person. The possibility for the drugs to move to a large number of bio molecular targets and lack of personalization are the major reasons for this. The multi targeting of drugs and resulted drug resistance and side effects can be minimized by designing and developing personalized drugs. Retro metabolic design strategy helps in generating promising molecules with less toxicity and side effects. Keywords: BRCA-1, chemical drug delivery systems, effective drug response, personalized drugs, retro-metabolic design, soft drug.