Synthetic lethality: emerging targets and opportunities in melanoma
Nicola Thompson, David J. Adams, Marco Ranzani · Pigment Cell & Melanoma Research · 2017
Great progress has been made in the treatment of melanoma through use of targeted therapies and immunotherapy. One approach that has not been fully explored is synthetic lethality, which exploits somatically acquired changes, usually driver mutations, to specifically kill tumour cells. We outline the various approaches that may be applied to identify synthetic lethal interactions and define how these interactions may drive drug discovery efforts.