caspo: a toolbox for automated reasoning on the response of logical signaling networks families
Santiago Videla, Julio Sáez-Rodríguez, Carito Guziołowski, Anne Siegel · Bioinformatics · 2016
Summary: We introduce the caspo toolbox, a python package implementing a workflow for reasoning on logical networks families. Our software allows researchers to (i) a family of logical networks derived from a given topology and explaining the experimental response to various perturbations; (ii) all logical networks in a given family by their input-output behaviors; (iii) the response of the system to every possible perturbation based on the ensemble of predictions; (iv) new experimental perturbations to discriminate among a family of logical networks; and (v) a family of logical networks by finding all interventions strategies forcing a set of targets into a desired steady state. Availability and Implementation: caspo is open-source software distributed under the GPLv3 license. Source code is publicly hosted at http://github.com/bioasp/caspo . Contact: [email protected].