The rationale of rheological pharmacological strategy
E. Ott, Franz Fazekas, H. Valetitsch, Eugen Körner, Helga Lechner · Clinical Hemorheology and Microcirculation · 1986
The involvement of haemorheologic variables in disturbed blood flow conditions of the brain can be globally verified as an increase of blood viscosity whereby hyperfibrinogenaemia, hyperaggregability of platelets and of erytrocytes and impaired erythrocyte flexibility as well as relative polycythaemia are the major contributing factors. Haemorheological disturbances are amenable to therapeutic intervention and various concepts have been established with the aim to lower blood viscosity (haemodilution), suppressing platelet hyperreactivity (ASA, pentoxifylline) and improving erythrocyte flexibility (pentoxifylline).