On Using Information-Theoretic Quantities in Characterization Dissimilarity of DNA Strings
Faruil Mohd-Zaid, Xiaoping Shen, Katheryn A. Farris · 2012
To discern similarity and differences in partial DNA strings based on dissimilarity (distance/difference) among the various SNPs, one of the challenge aspects is to select felicitous metrics or measurements. Some of information theoretic quantities are often employed in practice. Unfortunately, certain information-theoretic variables for example, information distance and mutual information, may not yield consistent results for decision-making. In this paper, we investigate the consistency of information theoretic quantities Experiments are designed to show that the selection of measures and metrics in information-theoretic based analysis is crucial for decision-making. Future possible research directions are discussed.