Platform AK: Membrane Structure II
Protein-Lipid Interactions, Hermann-Josef Kaiser, Daniel Lingwood, Ilya Levental, Julian Weghuber, Stefan Sunzenauer, Mario O. Brameshuber, Stefan Wieser, Lawrence Rajendran, Gerhard J. Schütz · 2010
amyloidogenesis leads to an aggregation free energy landscape. We define theroles of and propose a classification scheme for different oligomeric speciesbased on their location on the aggregation free energy landscape. We relatethedifferenttypesofoligomerstotheamyloidcascadehypothesisandthetoxicoligomer hypothesis for amyloid-related diseases. We discuss existing kineticmechanismsinterms ofthedifferenttypesof oligomers.Weprovideapossibleresolution to the toxic oligomer-amyloid coincidence.2189-PlatAmyloid-Like Cross-Beta Structure Polymorphism: An Energetic Point ofViewXavierPeriole