Pharmacogenetic GWAS Meta-Analysis of LDL Cholesterol Response to Statins
Stella Trompet, Iris Postmus, HA Deshmukh, Barnes, BM Psaty, J.‐C. Tardif, G. A. Hitman, R M Krauss, J. Wouter Jukema · Queen Mary Research Online (Queen Mary University of London) · 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects.We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS.Moreover, we confirm the previously described associations with APOE and LPA.Our findings advance the understanding of the pharmacogenetic architecture of statin response.