Solid State Stability of Cholesterol Preliminary kinetic analysis
Lenuţa-Maria Şuta, Gabriela Vlase, Titus Vlase, Tudor Rareș Olariu, Ionela Belu, Codrut Ivan, Cristian Andrei Sarău, Germaine Savoiu-Balint, Lavinia Stelea, Adriana Ledeţi, Pharmacy Victor Babes · 2016
Kinetic analysis is a powerful tool of characterization for degradative processes which involve bioactive compounds. In this study, we set our goal in the preliminary kinetic analysis for the decomposition processes of cholesterol under non-isothermal conditions, by employing two methods proposed by Kissinger: the classical Kissinger method vs. isoconversional Kissinger-Akahira-Sunose method. The obtained results by employing the two methods suggest the superiority of the isoconversional method. The mean value for activation energies were obtained as follows: 82.7 kJ/mol by using Kissinger method vs. 100.8±3.1 kJ/mol by using KAS method. A discussion for the differences between these values is presented.