Clinical approach with optical imaging instrument. Perspective analysis on 617 young females
Viviana Frattini, L. Ghisoni, Anna Glória Fonseca Teodoro, Sergio Orefice · 2011
Clinical approach with optical imaging instrument. Perspective analysis on 617 young females. Aim. The present perspective study sets out to de- termine the diagnostic accuracy of Dynamic Optical Breast Imaging (DOBI) in conjunction with ultra- sound systems for the prevention, diagnosis and monitoring of breast cancer in young females by means of a non-invasive technology examination. This examination methodology can represent a me- thodical support in uncertain and particular neo- plasms or an alternative approach to breast imaging especially for young women. Methodologies and systems. This study was conduct- ed on 617 young females aged 25-39 with clinical risk of developing a cancer or because of their breast den- sity there is suspicion of breast cancer. Standard imaging - All patients were submitted to clinical in- vestigation by means of both ultrasound (US) and dynamic optical breast imaging (DOBI). When both US and DOBI clinical results were positive for neo- plasm, the second step consisted of a surgical biopsy. If only US or DOBI showed positive for neoplasm those patients were submitted to core biopsy. Imag- ing technique - Diffuse Optical Imaging using near infrared light (640 nm) and recording the reaction of breast tissue to a compression stimulus that induces change in blood flow. Results. The dynamic optical imaging showed a sta- tistical difference (p<0.001) in patient analyses com- pared with ultrasound. In this study, the dynamic op- tical breast imaging had a sensitivity equal to 98%.and a specificity to 87%. Conclusion. This non-invasive, imaging-based methodology has a high potential for breast cancer prevention independent of breast size, density or hormonal status. It is particularly suitable for the younger female population whose breast tissue is SOMMARIO Studio clinico mediante dinamica ottica mammaria per immagini. Analisi prospettica in 617 donne con