Potential co-targets of isoniazid from protein-protein interaction network analysis
Tilahun Melak, Sunita Gakkhar · Drug Designing Open Access · 2015
Background: Tuberculosis (TB) is overwhelmingly a serious global public health problem by being the cause of mortality and morbidity of millions every year. This is mainly due to the emergence of drug-resistance varieties of TB. In spite of the implementations of several strategies, the resistance forms are still in rise and drug resistance remains the main threat for management, control and eradication programs of TB. As a result one approach to deal with the problem is protecting the emergence of resistance. In this analysis, maximum flow approach has been used to identify potential co-targets for isonisid which is one of the most widely used drug for the treatment of TB.