Link prediction in multilayered network
Elena Sugis · Figshare · 2016
Dataset consists of 5 files. First 4 files describe protein-protein interactions(PPI) in homo sapiens. They are obtained from IntAct database(http://www.ebi.ac.uk/intact/).Selected interaction are filtered based on MI score >= 0.45 from IntAct and considered to be highly confident. Protein names are translated to unique Ensemble(http://www.ensembl.org/index.html) gene identifiers (ENSG). 1. Dataset containing expert curated interactions related to Parkinson's disease parkinson_intact_int_PPI.txt 2. All highly confident interactions in hs available in IntAct database intact_int.txt 3. Aumatically curated interactions related to synaptic activity synapse_intact_int.txt 4. Dataset containing expert curated interactions related to Alzheimer's diseasealz_intact_int_PPI.txtThe 5th file describes genes, that are coexpressed in the Alzheimer's patients and healthy individuals. Correlation profiles are calculated using the set of microarray data obtained from ArrayExpress database (https://www.ebi.ac.uk/arrayexpress/). Final coexpression score is calculated by applying Robust Rank Aggregation method to aggregate correlation scores in individual microarray datasets.Coexpression scores are filtered based on pvalue <=0.00001. Gene names are translated to unique Ensemble(http://www.ensembl.org/index.html) gene identifiers (ENSG). alzcoexp_int_31052016.txt