Response to “Complexity vs. Simplicity: The Winner Is?” Mechanism‐Based Classifiers Provide More Than Just Classification
Megan Cummins Lancaster, EA Sobie · Clinical Pharmacology & Therapeutics · 2016
with a fully in vitro assay involving ionic current measurements, mathematical modeling, and drug effects assessed in cells.Our study 1 shows how mechanism-based modeling can be useful not only for synthesizing results after experiments have been performed, but also for prioritizing the experiments that will be part of the CiPA.Thus, although we agree with Dr. Mistry that simple classification systems can indeed be useful, it's important to emphasize that mechanism-based simulations, which account for the underlying biological complexity, can provide insight and actionable predictions that are generally not obtained from simple, empirical approaches.