In Vitro Cytotoxicity Effect of Kaempferol in Breast Cancer Cell Lines MCF-7 and Lung Cancer Cell Lines A459
Ramesh Londonkar, Basavarajeshwari S. Awanti · International Journal of Current Microbiology and Applied Sciences · 2016
In this study cytotoxic effect of kaempferol isolated from Vigna unguiculata was evaluated on breast cancer (MCF-7) and lung cancer A459 cell lines. MCF-7 and A459 cells were cultured in DMEM medium and incubated with different concentrations (100, 50, 25, 12.5, 6.25 µg/ml) of kaempferol .The cell viability was assessed by MTT assay. Kaempferol has decreased malignant cells in a concentration dependent manner. The IC50 values in MCF-7 and A459 cells were determined as 90.28 ± 4.2 µg/ml and 35.80 ± 0.4 µg/ml respectively. It may be concluded that kaempferol can cause cell death in MCF-7 and A459 cancer cells which is considered as a promising chemotherapeutic agent in breast cancer and lung cancer treatment.