Use of distance-based topological indices in modeling antihypertensive activity: Case of 2-aryl-imino-imidazolidines
Vijay K. Agrawal, Sneha Karmarkar, Padmakar V. Khadikar, Shachi Shrivastava, Istavan Lukovits · INDIAN JOURNAL OF CHEMISTRY- SECTION A · 2003
This paper describes topological modeling of antihyperensive activity of 2-aryl-imino-imidazolidines. A large pool of distance-based topological indices consisting of W, B, Χ, J, Sz, and log RB is initially used for this purpose. An excellent model is obtained in multi-parametric regression containing Χ and logRB along with two indicator parameters.