QSAR study on 5,6-dihydro-2-pyrones as HIV-1 protease inhibitors
Vijay K. Agrawal, Krishna Mishra, Jyoti Singh, Padmakar V. Khadikar · ARKIVOC · 2006
The paper describes QSAR studies on HIV-1 protease inhibitors using distance-based topological indices.A series of 5,6-dihydro-2-pyrones were used as HIV-1 protease inhibitors.The regression analysis of the data has shown that a tetra-parametric model containing topological indices and a pair of indicator parameters gives excellent results.The inhibitory activity is expressed as logIC 50 .