SP-0615: How to optimise the potential of SBRT
Piet Ost · Radiotherapy and Oncology · 2016
vivo data available, although this is a more appropriate reflection of the complex biological response.RBE is often established as measured by cell death, but emerging evidence also demonstrate an altered response in the surviving cells.This is both evident for high LET radiation, but also for proton radiation.This differential biological effect is not only relevant in the tumour, but also in the normal tissue.Current research in particle radiobiology is, in addition to the RBE, focusing on the molecular tissue response, and on the signalling pathways.Gene expression response in a panel of primary human fibroblasts, established from patients with known response to xray radiation in regards to late tissue damage, irradiated in vitro with different radiation qualities, has evaluated the effect of particle irradiation at different positions in the beam.This enlightens the heterogeneity in patient response to proton irradiation, individual biological variations and the differential effect of proton irradiation.This presentation will focus on the available experimental data on normal tissue response after irradiation with protons or heavier ions.