Network Ethnopharmacology Approaches for Formulation discovery
Bhushan Patwardhan, Uma Chandran · 2015
Lifestyle disorders like obesity, diabetes, cardiovascular diseases, and cancers are difficult to manage using one drug-one target approach and so require a multi-targeted approach. Any drug-whether chemical, botanical or biological-will have inherent limitations if it is focused only on a single target when dealing with polygenic syndromes. A new branch known as network pharmacology which integrates systems biology and computational biology has emerged to study drug interactions with multiple targets. Several traditional multi-botanical formulations are widely used globally; however, their rationale and scientific evidence for pharmacodynamic actions remain insufficient. A systematic study of network ethnopharmacologynetwork pharmacology of medicinal botanicalsis considered as promising approach to understand the scientific basis of intelligent formulations which would facilitate transition from single target based drug discovery to multi-target based rational formulation discovery.This article briefly describesnetwork pharmacology and demonstrates the Rasayana property of Triphalain the light of this emerging technique.