QSAR of substituted N-benzyl piperidines in the GBR series
Abhishek Kumar Srivastava, Meetu Jaiswal, ARCHANA ARCHANA, Shraddha Chaurasia · Zenodo (CERN European Organization for Nuclear Research) · 2008
Department of Chemistry, University of Allahabad, Al\ahabad-211 002, Uttar Pradesh, India E-mail : [email protected] Manuscript received 12 March 2007, revised 16 April 2008, accepted 16 May 2008 Quantitative structure activity relationship (QSAR) studies on substituted piperidine in the GBR series have been made. Significant correlations were been obtained by multiparametric regression by using structural parameters with indicator parameters. The dopamine transporter (DAT) inhibitory activity of these compounds was found to increase with equalized electronegativity, hydrophobicity and bulk. The generated models were statistically validated using leave one out technique and cross validation methods.