Computer-Assisted Drug Receptor Mapping Analysis
Teri E. Klein, Conrad C. Huang, Thomas E. Ferrin, Robert Max Langridge, Corwin H. Hansch · ACS symposium series · 1986
KARMA is an interactive computer assisted drug design tool that incorporates quantitative structure-activity relationships (QSAR), conformational analysis, and three-dimensional graphics. It represents a novel approach to receptor mapping analysis when the x-ray structure of the receptor site is not known, KARMA utilizes real time interactive three-dimensional color computer graphics combined with numerical computations and symbolic manipulation techniques from the field of artificial intelligence.