The Extrathermodynamic Structure-Activity Correlations
Toshio Fujita · Advances in chemistry series · 1974
The background supporting the versatility of the Hansch approach is that it is in fact an extrathermodynamic approach to drug action. The information on the structure-activity relationship of various kinds of drugs is expressed as equations which provide a convenient way for comparative studies with simpler and similar model reactions to elucidate the mechanism of overall drug action without microscopic knowledge of complex processes occurring in vivo.