Variability of Information's Quantity as Starting Ergon Parameter
Carla Rossi · Acta geneticae medicae et gemellologiae · 1974
The problem of discordance for age-dependence disease among MZ twins is considered first.A brief outline is given of the author's unified theory of the aetiology and pathogenesis of diseases with a reproducible agedistribution.Theory states that each welldefined age-dependent disease is initiated by a characteristic set of random gene mutations in stem cells of the central system of growth control.The random nature of the initiating events is a common source of discordance for age-dependent disease among MZ twins.A method of allowing for incomplete penetrance is discussed in relation to Abe's (1969) study of the onset of schizophrenia in MZ twins.Attention is drawn to the severe difficulties posed by genetic heterogeneity in certain categories of disease.Possible sources of discordance between MZ twins, initiated during embryogenesis, are described with reference both to congenital abnormalities and agedependent disease.Methods of distinguishing between the several possibilities are described.