Key to the Biology code of the Chemical-Biological Coordination Center
Philip G. Seitner · National Academy of Sciences-National Research Council eBooks · 1960
AColumn 9 solid (the state prior to introduction into the water, saline, etc. ) would not serve any useful purpose in this situation, this field should be coded with the state of the compound in the host water or nutrient (i.e. , the state as applied to the test organism) rather than with the state when added to those hosts.6. Coding in Field A when the test compound has been applied to a surface as a residue Occasionally, a test compound is introduced onto a surface (or in a cloth, filter paper, etc. ) in an organic solvent, for example, which is subsequently allowed to evaporate, leaving the test compound as a residue. (I) If the technique dictates that the test organism is then exposed to the residue, Field A is correctly coded with the state when applied to the surface, according to Division 4 above.(II) However, if this treated surface (e. g. , an aquarium inner surface, microscope depression slide, Petri dish, a filter paper disc, etc. ) is then immersed in water, for a test with aquatic organisms, "water" is to be coded in Field J, nothing need be coded in Field C, and Field A is to be coded only if it is known or stated that the compound is completely soluble in water; otherwise, Field A will be left uncoded.7. Coding in Field A when the test compound is a gas If the test compound is administered as a gas and its concentration is expressed by the author only in terms of this gas (e. g. , per cent test gas in N, O z , or air) which is subsequently streamed through (1) a bath or perfusate of an organ, tissue, or immersed organism, or (2) a suspending medium of a tissue macerate or an enzyme-containing secretion (e. g. , milk), the concentration of the test compound in the gas will be coded in Field M. Therefore, in this case, Field A must be coded with "gas", Symbol 1, and Field C need not be coded, since the suspending solvent is implied in coding the preparation as a homogenate (Field G) or secretion (Field I) or in coding the diluent of the homogenate (Field J).Note, however, that if the author should actually have determined the dissolved con- centration of the test compound, coding in Fields M and C should be based on that concentration and solvent and Field A should be coded with "solution", Symbol 4.8. Indication of information on correlation between chemical structure and biological activity