The Ghrelin System
Andrea Silvio Benso, Casanueva, Felipe F., Ghigo, Ezio, Riccarda Granata · Endocrine development · 2013
The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin‚ a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure