Design, Preliminary QSAR Study And Drug-Likeness Score Of Isobenzofuran Analogues
C. Iyyappan, Chaudhari Praveen, K. L. Hemalatha, K. Girija · 2010
In order to create novel antidepressants without oxidative tissue damage, less side effects and good bioavailability, structurally simple selective serotonin reuptake inhibitors with a isobenzofuran skeleton were designed based on the SAR of the target molecule- Citalopram and Talopram. As a result, designed molecules obey the Lipinski rule of 5 and also give moderate to good druglikness score.