QSAR studies of hydrazone uncouplers of oxidative phosphorylation.
David Alan Winkler, George Holan, D. R. J. Smith, E. J. Middleton, NK Hart, Kurt Rihs, K. W. Smith · PubMed · 1988
Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pKa and atom charges.